No, it won't affect photo quality at all.

Cleaning privacy information only removes hidden data from photos, such as location information, device model, and shooting time. You can't see this information, and it doesn't affect the visual appearance of the photo.

The photo itself won't change. Pixels, colors, and clarity are exactly the same. Just the hidden privacy information is removed.

You can clean with confidence. The photo looks exactly the same, just safer.

So, if you're concerned about privacy, you can clean with confidence without worrying about photo quality.